Residual risk of transfusion in Ghana
Identifieur interne : 001126 ( Main/Exploration ); précédent : 001125; suivant : 001127Residual risk of transfusion in Ghana
Auteurs : Daniel Candotti [Royaume-Uni] ; Francis Sarkodie [Ghana] ; Jean-Pierre Allain [Royaume-Uni]Source :
- British journal of haematology [ 0007-1048 ] ; 2001.
Descripteurs français
- KwdFr :
- ARN viral (analyse), Adulte, Femelle, Ghana, Hepacivirus (génétique), Humains, Hépatite C (génétique), Hépatite C (transmission), Infections à VIH (génétique), Infections à VIH (transmission), Mâle, Prévalence, Risque, Transfusion sanguine (effets indésirables), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique).
- MESH :
- analyse : ARN viral.
- effets indésirables : Transfusion sanguine.
- génétique : Hepacivirus, Hépatite C, Infections à VIH, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Adult, Blood Transfusion (adverse effects), Blood donor, Female, Ghana, HIV Infections (genetics), HIV Infections (transmission), HIV-1 (genetics), Hepacivirus (genetics), Hepatitis C (genetics), Hepatitis C (transmission), Hepatitis C virus, Human, Human immunodeficiency virus, Humans, Infectious risk, Male, Prevalence, RNA, Viral (analysis), Risk, Transfusion, Transfusion safety.
- MESH :
- chemical , analysis : RNA, Viral.
- geographic : Ghana.
- adverse effects : Blood Transfusion.
- genetics : HIV Infections, HIV-1, Hepacivirus, Hepatitis C.
- transmission : HIV Infections, Hepatitis C.
- Adult, Female, Humans, Male, Prevalence, Risk.
Abstract
Plasma samples from replacement and volunteer blood donors in Kumasi, Ghana were pooled and tested using a duplex human immunodeficiency virus (HIV) and hepatitis C virus (HCV) RNA detection method. Individual plasmas constitutive of reactive pools were confirmed using reverse transcription-polymerase chain reaction. HIV and HCV infections were significantly higher in 1569 replacement donors than in 1169 volunteers; 2.4 and 1.7 versus 0.3 and 0.7% respectively (P < 0.01). Two duplex RNA-positive plasma pools contained a confirmed/seronegative HIV or HCV RNA individual plasma. The residual post-transfusion risk of HIV and HCV infection of blood collected from replacement blood donors ranged between 1:260 and 1:16 393 after screening for anti-HIV p24 antigen and anti-HCV, These data indicate that in high-prevalence HIV and HCV blood donor populations, a substantial residual post-transfusion risk of infection remains. This risk might be reduced by collecting blood in younger volunteer donors or by genomic screening.
Affiliations:
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Le document en format XML
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aut.</sZ></inist:fA14><country>Ghana</country><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Division of Transfusion Medicine, Department of Haematology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author></analytic><series><title level="j" type="main">British journal of haematology</title><title level="j" type="abbreviated">Br. j. haematol.</title><idno type="ISSN">0007-1048</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">British journal of haematology</title><title level="j" type="abbreviated">Br. j. haematol.</title><idno type="ISSN">0007-1048</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Blood Transfusion (adverse effects)</term><term>Blood donor</term><term>Female</term><term>Ghana</term><term>HIV Infections (genetics)</term><term>HIV Infections (transmission)</term><term>HIV-1 (genetics)</term><term>Hepacivirus (genetics)</term><term>Hepatitis C (genetics)</term><term>Hepatitis C (transmission)</term><term>Hepatitis C virus</term><term>Human</term><term>Human immunodeficiency virus</term><term>Humans</term><term>Infectious risk</term><term>Male</term><term>Prevalence</term><term>RNA, Viral (analysis)</term><term>Risk</term><term>Transfusion</term><term>Transfusion safety</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>Adulte</term><term>Femelle</term><term>Ghana</term><term>Hepacivirus (génétique)</term><term>Humains</term><term>Hépatite C (génétique)</term><term>Hépatite C (transmission)</term><term>Infections à VIH (génétique)</term><term>Infections à VIH (transmission)</term><term>Mâle</term><term>Prévalence</term><term>Risque</term><term>Transfusion sanguine (effets indésirables)</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Blood Transfusion</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Transfusion 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sang</term><term>Virus immunodéficience humaine</term><term>Virus hépatite C</term><term>Risque infectieux</term><term>Homme</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Plasma samples from replacement and volunteer blood donors in Kumasi, Ghana were pooled and tested using a duplex human immunodeficiency virus (HIV) and hepatitis C virus (HCV) RNA detection method. Individual plasmas constitutive of reactive pools were confirmed using reverse transcription-polymerase chain reaction. HIV and HCV infections were significantly higher in 1569 replacement donors than in 1169 volunteers; 2.4 and 1.7 versus 0.3 and 0.7% respectively (P < 0.01). Two duplex RNA-positive plasma pools contained a confirmed/seronegative HIV or HCV RNA individual plasma. The residual post-transfusion risk of HIV and HCV infection of blood collected from replacement blood donors ranged between 1:260 and 1:16 393 after screening for anti-HIV p24 antigen and anti-HCV, These data indicate that in high-prevalence HIV and HCV blood donor populations, a substantial residual post-transfusion risk of infection remains. This risk might be reduced by collecting blood in younger volunteer donors or by genomic screening.</div></front></TEI><affiliations><list><country><li>Ghana</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li></region><settlement><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Candotti, Daniel" sort="Candotti, Daniel" uniqKey="Candotti D" first="Daniel" last="Candotti">Daniel Candotti</name></noRegion><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name></country><country name="Ghana"><noRegion><name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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